Multicolumn Distillation Plants in Large Volume Parenterals (LVPs)

In the pharmaceutical sector, Large Volume Parenterals (LVPs) such as IV fluids demand uncompromised water quality. At the heart of this requirement lies Water for Injection (WFI)—the foundation for safe and effective formulations. Multicolumn distillation plants have emerged as the gold standard, ensuring purity, efficiency, and compliance for high-volume production.

Production of Water for Injection (WFI)
High Purity Assurance
Energy Efficiency
Continuous and Reliable Supply
Regulatory Compliance & Validation

LVPs such as IV fluids (dextrose, saline, and ringer’s lactate) require WFI as their primary solvent. Multicolumn distillation systems deliver WFI in strict accordance with pharmacopeia standards (USP, EP, IP).
This guarantees that every drop of water meets the highest safety and quality benchmarks demanded by global healthcare.

Multicolumn distillation ensures the removal of endotoxins, volatile and non-volatile impurities, and microbial contamination. Its multi-effect design enhances efficiency while achieving very low conductivity and TOC levels.
Such purity is vital for LVPs, where even trace contaminants can compromise patient safety and product integrity.

Unlike single-effect distillation, multicolumn systems recycle heat across multiple stages, dramatically lowering energy consumption—critical for high-volume LVP manufacturing.
This efficiency not only reduces operational costs but also supports sustainable production practices.

LVP production is high-throughput and continuous, requiring a dependable source of sterile WFI. Multicolumn distillation systems are engineered for uninterrupted operation to meet constant demand.
Their reliability ensures that production cycles remain smooth, consistent, and free from costly downtime.

Designed and validated to meet cGMP, FDA, and EU guidelines, multicolumn systems align with stringent standards for injectable-grade water.
This compliance reassures manufacturers that their LVPs will withstand regulatory scrutiny across global markets.

Excellence Since 1985

Ravi Kiran Industries has been a pioneer in manufacturing distillation columns since 1985. With decades of expertise, the company continues to deliver advanced solutions that power pharmaceutical excellence worldwide.

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Samir Sampat